| 名稱 | TP53 p.R175H Reference Standard 標(biāo)準(zhǔn)品 | 
| 型號 | CBP10143 | 
| 報價 |  | 
| 特點 | TP53 p.R175H Reference Standard | 
產(chǎn)品搜索
相關(guān)文章
聯(lián)系我們
      聯(lián)系人:蔣經(jīng)理 
電話:4008750250
號碼:
手機:18066071954
地址:南京市棲霞區(qū)緯地路9號
Email: zhangxiangwen@cobioer.com
      
      
      
      
      
      
    
  電話:4008750250
號碼:
手機:18066071954
地址:南京市棲霞區(qū)緯地路9號
Email: zhangxiangwen@cobioer.com
					產(chǎn)品展示  / PRODUCTS
					
						基因檢測標(biāo)準(zhǔn)品 > Mutation  >  CBP10143TP53 p.R175H Reference Standard 標(biāo)準(zhǔn)品
            
              
					
				
				 
						- 詳細(xì)內(nèi)容
" _ue_custom_node_="true">
|  CBP10143 | |
| Format | Genomic DNA | 
| Description | TP53 R175H is a hotspot mutation that lies within the DNA binding domain of the Tp53 protein (PMID: 22713868). R175H results in decreased activation of Tp53 targets and interferes with activation by wild-type Tp53, leads to resistance to apoptosis, decreased genomic stability, and promotes tumorigenesis, and additionally confers a gain of function to Tp53, resulting in aberrant activation of gene transcription and enhanced cell migration (PMID: 10713666, PMID: 22114072, PMID: 19881536, PMID: 14743206). | 
| Technical Data | |
| DNA Change: | c.524G>A | 
| AA Change | p.R175H | 
| Mutation type | Substitution - Missense | 
| Zygosity | Homozygous | 
| Allelic Frequency | 100% | 
| Transcript | ENST00000269305 | 
| Cosmic ID | COSM10648 | 
| Chr position(GRCh37) | chr17:7578406 | 
| Buffer: | Tris-EDTA | 
| Product Information | |
| Intended Use | Research Use Only | 
| Unit Size | 1ug | 
| Concentration | Download for COA | 
| Purofication | Download for COA | 
| DNA electrophoresis | Download for COA | 
| Sanger sequencing | 
 | 
| Storage | 4℃ | 
| Expiry | 36 months from the date of manufacture | 




